Stress Reset
Stress Reset
Stress Reset is designed to maintain healthy cortisol levels and optimize neurotransmitter activity—the critical processes that keep your mind calm and resilient.
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Ingredients
• Withania Somnifera (Ashwagandha), 120mg
• Crocus sativus (Saffron), 28mg
• Sceletium Tortuosum (Kanna), 25mg
• Rhodiola Rosea (Fermented Salidrosides), 30mg
• Magnesium Bisglycinate, 84mg
• Cholecalciferol (Vitamin D3), 125mcg
• Dihydrohonokiol-B (Honokiol extract), 10mg
Capsules with caffeine contain:
• Caffeine Anhydrous, 100mg
• Camellia siensis (L-Theanine), 100mg
How To Use
Suggested Use: Adults, take two (2) capsules daily. Adjust to 1-3 capsules, depending on sensitivity or as recommended by your healthcare provider.
CAUTION: Always consult your healthcare professional before use, especially if you have a medical condition or are taking medication. Do not use if you are pregnant or nursing. Keep out of reach of children.
Clinically-proven, powerhouse ingredients for game-changing benefits.
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Cholecalciferol (Vitamin D3)
Promotes the production of serotonin
What is it? Our formula features 125 mcg (5,000 IU) of vitamin D3, the most active and absorbable form of vitamin D. Often called the “sunshine vitamin,” vitamin D3 plays a vital role in supporting a stable, positive mood and promoting mental clarity. It helps promote the production of serotonin—a neurotransmitter essential for emotional balance, stress resilience, and focus. Inadequate levels are common, especially during periods of low sunlight, and can contribute to low mood, brain fog, and fatigue. By including a high-potency dose of vitamin D3 in our Stress Reset formula, we help restore what your body may be missing—supporting emotional well-being, improving focus, and helping you stay clear, calm, and grounded through life’s demands.
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Dihydrohonokiol-B (Honokiol extract)
Supports GABAergic activity
What is it? Our formula features Dihydrohonokiol-B (DHH-B), a naturally derived compound found in magnolia bark. DHH-B has been studied for its interaction with GABA receptors, which play a key role in the body's natural stress response. By supporting GABAergic activity, DHH-B may help promote a sense of calm and relaxation during occasional stress. This ingredient is included in our Stress Reset formula to help support a balanced mood and maintain mental clarity without drowsiness.
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Rhodiola Rosea (Fermented Salidroside)
Supports neurotransmitter balance
What is it? Salidroside is a bioactive tyrosol glycoside found in Rhodiola rosea, an adaptogenic plant traditionally used to support resilience to physical and mental stress. Our formula features SalidroPure™, a highly purified form of salidroside produced through precision fermentation—ensuring a sustainable and stable alternative to wild-harvested rhodiola.
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Withania Somnifera (Ashwagandha)
Promotes stress relief
What is it? Ashwagandha, also known as “Indian Ginseng” or “Indian Winter Cherry,” is a powerful adaptogenic herb deeply rooted in Ayurvedic medicine. Traditionally used for stress relief, cognitive function, and overall vitality, it helps the body adapt to physical and mental stressors while promoting energy balance, emotional well-being, and resilience.
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Sceletium Tortuosum (Kanna)
Reduces occasional anxiety
What is it? Sceletium tortuosum, commonly known as kanna, has been traditionally used by the San and Khoikhoi tribes of South Africa for centuries to promote well-being, reduce stress, and enhance endurance. Historically, it was chewed, smoked, or brewed as a tea for mood enhancement, relaxation, and cognitive clarity.
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Crocus sativus (Saffron)
Enhances mood
What is it? Known as the “Golden Spice,” saffron has long been celebrated for its ability to support emotional well-being and help the body cope with occasional stress. Our premium saffron extract harnesses the potent bioactive compounds crocins and safranals—standardized to 7.5% and 1% respectively—to promote a positive mood, mental clarity, and relaxation.
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Magnesium Bisglycinate
Promotes a sense of calm
What is it? Our formula includes 600 mg of magnesium bisglycinate, delivering 84 mg of pure, absorbable magnesium. This highly bioavailable form is paired with glycine, an amino acid that enhances absorption and is gentle on digestion.
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Camellia sinensis (L-Theanine)
Reduces jitters
What is it? L-Theanine is a naturally occurring amino acid found in tea leaves, known for its ability to promote relaxation without sedation. It works by promoting alpha brain wave activity, a pattern associated with calm focus and mental clarity.
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Caffeine Anhydrous
Promotes focus and energy
What is it? Caffeine is a naturally occurring stimulant found in coffee, tea, and other plant sources, known for its ability to enhance alertness and mental energy. It works by blocking adenosine, a neurotransmitter that promotes relaxation, leading to increased wakefulness and focus.
Stress Reset has helped hundreds of thousands of customers focus—and follow through.
Don't just take our word for it. See for yourself what Thesis customers experience within 60 days of taking Stress Reset.
*These claims are based on a previous version of the Stress Reset formula, called Confidence. The data comes from an open-label consumer perception survey conducted in September 2024, which included a minimum of 37 customers who had been using that version for at least 60 days. Participants received a $10 rebate for sharing their feedback. The previous formula included Saffron, Ashwagandha, Magnesium, DHH-B, Zembrin®, and optionally caffeine and L-theanine. The formula has since been updated. A new study evaluating the current formula is planned, and updated claims are expected by December 2025.
NO UNNECESSARY FILLERS
100% VEGAN
NON-GMO
GAME-CHANGING RESULTS
QUALITY GUARANTEED
THIRD-PARTY TESTED
NO UNNECESSARY FILLERS
100% VEGAN
NON-GMO
GAME-CHANGING RESULTS
QUALITY GUARANTEED
THIRD-PARTY TESTED
Find more clarity, motivation, and stability over time.
Feel more grounded, fast
L-Theanine and Zembrin® promote calm focus and balance—so you can feel less reactive, faster.*
More calm, more clarity
Ashwagandha, Magnesium, and Saffron support cortisol balance, mood, and focus—making daily stress easier to manage.*
Respond, don’t react
Zembrin®, SalidroPure™, and DHH-B promote stress resilience, emotional steadiness, and clear, calm energy all day.*
Build true stress resilience
Ashwagandha, SalidroPure™, and Vitamin D support emotional balance, mental clarity, and lasting calm energy, even when life feels chaotic.*
Collapsible content
Passed Microbial Testing
Passed Microbial Testing
We analyze all of our formulas for microorganisms including bacteria, viruses, and fungi.
Passed Active Ingredients
Passed Active Ingredients
We verify that every formula contains the exact amounts of active ingredients listed on the label.
Passed Heavy Metal Testing
Passed Heavy Metal Testing
We screen each batch for harmful heavy metals like lead, arsenic, cadmium, and mercury.
Passed Pesticide Testing
Passed Pesticide Testing
We test raw materials to ensure they’re free from pesticide residues, even trace amounts.
Nootropics needed pharmaceutical-grade testing. We delivered.
Nootropics needed pharmaceutical-grade testing. We delivered.
Rigorous testing and comprehensive consumer trials come standard for pharmaceutical drugs, but not nootropics. We weren’t satisfied with existing scientific data around active ingredients, so when we founded Thesis, we started to collect our own.
Today, we’ve conducted thousands of trials, and collected data from 7.3 million customers and counting. Our 5-part formulation process builds from all of this so you can trust that when you choose Thesis, you’re not guessing with nootropics. You’re choosing a cognitive conditioner that'll actually work.
Clinically researched. Precisely formulated.
Clinically researched. Precisely formulated.
Thesis uses isolated, plant-derived compounds rather than blends or extractions. This allows us to control consistency and experiment to determine the most effective dose of each ingredient to get the best results possible.
Many nootropics make baseless claims. We conduct real-world testing.
Many nootropics make baseless claims. We conduct real-world testing.
We conduct continuous beta testing and open-label trials to assess real-world effectiveness. Our studies are designed with the rigor and ethical standards typically reserved for pharmaceutical clinical trials.
Thesis has run over 30 beta tests
with real customers.
Thesis reads and analyzes 700+
studies when formulating.
Thesis products have been evaluated by 7.3 million customers.
An informed hypothesis
An informed hypothesis
Thesis’ science team and board of scientific advisors are constantly iterating based on our own data, new studies and cognitive research. Every process begins with a systematic review of literature that helps inform a hypothesis we set out to validate at scale. We then formulate based on these hypotheses.
Blind trials.
Blind trials.
With formulas in hand, we conduct a series of two week long blind trials. Hundreds of participants receive our formulas and a questionnaire based on a set of scientific criteria designed to standardize the results.
Analyze and iterate.
Analyze and iterate.
At the end of a trial all data is analyzed to determine the most effective formulation and that formula is rolled at a larger scale, evaluated again and improved if necessary. Product development is a continuous process at Thesis, we’re always iterating, testing and improving.
We’re devoted to continual improvement.
We’re devoted to continual improvement.
Our process is driven by two questions: why and how. We’re constantly reevaluating every decision we’ve made, and asking new questions in search of better outcomes for those who love and trust Thesis.
Here are the latest questions that drive what we do:
Which ingredient combinations most effectively support distraction-proof focus in a dopamine-saturated world?
Modern life hijacks attention with constant pings, scrolls, and dopamine spikes. Clarity targets this head-on by combining Citicoline, Lion’s Mane, and 7,8-DHF to promote neuroplasticity, acetylcholine signaling, and dopamine regulation. This stack helps support distraction resistance, sustained attention, and the deep work required for modern cognitive demands.
How can we support our brains to thrive now and stay sharp for decades to come?
Cognitive health isn’t just about a better workday. It’s about protecting what makes you you. From dopamine and Acetylcholine for daily drive and focus, to Sulforaphane, Spermidine, and mitochondrial activators for long-term resilience, our formulas are designed to support both high performance today and brain longevity tomorrow.
How does Stress Reset better support serum cortisol levels compared to previous formulations?
Stress Reset combines Shoden® Ashwagandha, clinically shown to reduce cortisol by up to 67% and occasional anxiety by 59%, with Zembrin® and Salidrosides for sharper mood regulation and cognitive flexibility. This version supports serotonin, dopamine, and alpha wave activity, without sedation or crash.
Reviews
FAQ'S
What are nootropics, and how do they work?
What are nootropics, and how do they work?
Nootropics are supplements that support cognitive health. They've been shown to boost motivation and focus, spark creativity, maintain long-term memory, balance mood, and more.
These potent ingredients—found in nature—help support cognition. Some nootropics, like Ashwagandha and Lion’s Mane, have been used for thousands of years. Others, like caffeine, may already be part of your daily routine.
Nootropics work by increasing brain activity by delivering more oxygen and nutrients to the brain, helping brain cells communicate better and increasing neuroplasticity–how adaptable your brain is to learning and experiencing.
Consistent, long-term nootropic use fosters healthy neuron growth, improving overall brain health and function, and supporting memory, focus, and overall mental performance.
Where can I find more information on each ingredient?
Where can I find more information on each ingredient?
If you want to learn more about the science behind each ingredient, check out the Ingredients page on our website.
To discuss the function or science behind our ingredients, speak with our Customer Care Team at 646-647-3599 or email us at hello@takethesis.com.
What’s unique about Thesis nootropics?
What’s unique about Thesis nootropics?
Instead of a one-size-fits-all approach, Thesis offers unique formulas made with clinically studied ingredients that complement one another to target different cognitive goals. Whether you’re looking to sharpen your working memory, boost mental clarity, or stay calm under pressure, there’s a formula to meet you where you are.
Can I open the capsules and pour them into water?
Can I open the capsules and pour them into water?
You can — but we don’t recommend it. We encapsulate the ingredients because they have a strong, unpleasant taste. If you have a hard time swallowing capsules, it is perfectly safe to mix the contents into a smoothie, juice, or flavored drink to help mask the taste.
What are the long-term effects?
What are the long-term effects?
In clinical trials, none of our ingredients show negative long-term effects. Many nootropics become more effective over time due to the compounding effects on brain health and the structural integrity of neurons.
Early research studying the long-term effects of certain nootropics ingredients shows improvement in cognitive traits like memory retention, cognitive flexibility, and focus following persistent use.
What is a daily dose?
What is a daily dose?
A daily dose is a single packet, containing two or three brown capsules and one white capsule that contains caffeine. If you ordered a caffeine-free version, your packet will only contain the brown capsules. There are six packets in each box of your formula, e.g., Energy, Clarity, Motivation are all “formulas”. Most people take one packet per day, containing all of the capsules enclosed.
Does recommended dosage vary by individual factors like weight?
Does recommended dosage vary by individual factors like weight?
We standardize our doses across our different ingredient blends based on clinically studied dosages. However, individual factors like weight, metabolism, and tolerance can sometimes impact effectiveness.
If you want guidance on how to change the dose to reach the desired effects, give us a call so we can help adjust.
It’s important to speak with your primary medical provider before starting any new supplement or altering any course of medication.
Can I take more than one formula per day?
Can I take more than one formula per day?
Thesis was designed to be taken once daily. However, we understand that your needs may vary. You can safely take up to two formulas (e.g., Energy and Creativity) in a given day if you prefer.
We recommend spacing each formula by at least 4 hours to avoid any potential interactions or absorption issues. For guidance on combining formulas safely and effectively, speak with our Customer Care Team who can tailor recommendations to your specific needs and goals. Additionally, we always recommend speaking with your healthcare provider before starting a new supplement routine.
Will I become reliant on taking my formula?
Will I become reliant on taking my formula?
No, you won’t develop a dependency on any of our formulas. Because nootropics are non-habit-forming compounds, you have the flexibility to pause or stop taking them without experiencing unwanted side effects.
Can I take Thesis if I’m under 18?
Can I take Thesis if I’m under 18?
Our product is one of the most comprehensive nootropics systems on the market and our ingredients are backed by hundreds of clinical research papers.
Unfortunately, the research conducted on these ingredients did not include participants who were under the age of 18. We advise against children taking our product and encourage you to consult a pediatric healthcare provider for advice tailored to minors.
Is it safe to take if I’m pregnant or breastfeeding?
Is it safe to take if I’m pregnant or breastfeeding?
Our product is one of the most comprehensive nootropics systems on the market and our ingredients are backed by hundreds of clinical research papers.
Unfortunately, the research conducted on these ingredients did not include participants who were pregnant, nursing, or breastfeeding. For that reason, you should always consult your healthcare provider before starting any new supplement to ensure it is safe for you and your baby.
Are there any known side effects?
Are there any known side effects?
Everybody responds to supplements differently. Side effects are rare but possible, especially when introducing new supplements to your routine. They can include a mild upset stomach or mild headache, and are often remedied by taking your formula with food instead of on an empty stomach.
